Human Studies Raise Similar Concerns
These laboratory findings are consistent with evidence from large observational studies in humans. Several analyses have found that individuals with higher blood levels of erythritol face a significantly increased risk of cardiovascular events, including heart attacks and strokes.
One major study reported that participants with the highest erythritol levels were nearly twice as likely to experience a major cardiac event compared with those with lower levels.
Important Limitations
Despite the concerning results, the researchers emphasize that the study was conducted on isolated cells in laboratory conditions. Such models cannot fully replicate the complexity of human blood vessels and living systems.
Further research using advanced models—such as “blood-vessel-on-a-chip” technology—and clinical studies will be necessary to confirm whether these effects occur in real-world conditions.
Why Erythritol Is So Widely Used
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